Beilstein J. Org. Chem.2013,9, 2916–2924, doi:10.3762/bjoc.9.328
for linked, fused or merged bivalent derivatives of 1.
Keywords: allotopic; bivalent ligand; designedmultipleligand; JDTic; κ-opioid receptor; natural products; Salvinorin A; Introduction
The structure–activity relationships of salvinorin A (1), a potent and selective κ (kappa) opioid, have been
PDF
Graphical Abstract
Figure 1:
Binding affinities of salvinorin A (1) and furan derivatives for κ-OR [5].